This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]
Transcription factors with Perturb-seq knockdown data for MET. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MET upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MET, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:116,499,027–116,500,982 | 172.7 kb | Distal (>10kb) Multiome | 687 | |
| chr7:116,524,296–116,527,064 | 147.6 kb | Distal (>10kb) Multiome | 789 | |
| chr7:116,671,633–116,673,220 | 183 bp | At TSS Multiome | 926 | |
| chr7:116,674,608–116,675,038 | 2.4 kb | Proximal (<10kb) | 141 | |
| chr7:116,675,444–116,675,714 | 3.2 kb | Proximal (<10kb) | 25 | |
| chr7:116,861,960–116,863,478 | 190.2 kb | Distal (>10kb) Multiome | 893 | |
| chr7:116,876,604–116,877,522 | 204.6 kb | Distal (>10kb) Multiome | 450 | |
| chr7:116,952,833–116,954,651 | 281.4 kb | Distal (>10kb) Multiome | 944 |
Genomic view of the MET locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.