GC4

Gene Cluster 1026 genes

Ribosomal RNA metabolism and ribonucleoprotein biogenesis

This 1,049-gene module includes BRCA1, MYC, AR, COMT, and BCL2, and is predominantly enriched for ribonucleoprotein complex biogenesis, ribosome biogenesis, and rRNA metabolic processes. Knockdown of FOXA2 activates this module. Knockdown of ARID1A represses this module.

Key terms: ribonucleoprotein complex biogenesis ribosome biogenesis rRNA metabolic process rRNA processing RNA processing Notable genes: BRCA1 MYC AR COMT BCL2 CCND1 CXCL12 HMGB1 Top TFs: ARID1A SMARCC1 CNBP MIXL1 FOXH1

1026 member genes 323 TF regulators

TF Regulatory Network

Direction indicates the effect of TF knockdown on this gene cluster (↑ = KD upregulates; ↓ = KD downregulates).

Perturbation + Binding ↑ ↓

Perturbation only ↑ ↓

Binding only

TF	Dir	NES	padj	Bind	OR

Module Genes

Genes assigned to this temporal expression cluster (mfuzz).

Gene	Type	Publications