This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for BCL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BCL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BCL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:62,596,005–62,597,172 | 541.9 kb | Distal (>10kb) Multiome HiCAR | 194 | |
| chr18:63,074,960–63,075,425 | 63.2 kb | Distal (>10kb) Multiome | 388 | |
| chr18:63,138,172–63,139,185 | 305 bp | At TSS Multiome HiCAR | 304 | |
| chr18:63,317,892–63,318,708 | 179.8 kb | Distal (>10kb) Multiome HiCAR | 432 | |
| chr18:63,319,616–63,321,341 | 181.8 kb | Distal (>10kb) Multiome HiCAR | 620 | |
| chr18:63,322,885–63,323,292 | 4.2 kb | Proximal (<10kb) | 223 | |
| chr18:63,365,958–63,368,108 | 229.1 kb | Distal (>10kb) Multiome | 1040 | |
| chr18:63,421,682–63,423,287 | 284.1 kb | Distal (>10kb) Multiome | 939 |
Genomic view of the BCL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.