The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers. [provided by RefSeq, Dec 2019]
Transcription factors with Perturb-seq knockdown data for CCND1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCND1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCND1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:69,122,768–69,123,396 | 518.2 kb | Distal (>10kb) Multiome HiCAR | 565 | |
| chr11:69,442,945–69,443,770 | 197.6 kb | Distal (>10kb) Multiome | 754 | |
| chr11:69,634,094–69,634,352 | 6.8 kb | Proximal (<10kb) | 17 | |
| chr11:69,636,341–69,637,110 | 4.5 kb | Proximal (<10kb) Multiome | 292 | |
| chr11:69,637,726–69,639,648 | 3.0 kb | Proximal (<10kb) Multiome | 644 | |
| chr11:69,640,489–69,642,473 | 14 bp | At TSS Multiome | 770 | |
| chr11:69,642,597–69,643,808 | 2.3 kb | Proximal (<10kb) Multiome | 599 | |
| chr11:69,674,751–69,675,727 | 34.2 kb | Distal (>10kb) Multiome | 862 | |
| chr11:69,700,636–69,701,130 | 59.7 kb | Distal (>10kb) Multiome | 508 | |
| chr11:69,703,191–69,705,251 | 63.6 kb | Distal (>10kb) Multiome | 446 | |
| chr11:69,773,877–69,776,365 | 134.3 kb | Distal (>10kb) Multiome | 239 |
Genomic view of the CCND1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.