This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Transcription factors with Perturb-seq knockdown data for CXCL12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CXCL12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CXCL12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:44,233,283–44,234,118 | 151.3 kb | Distal (>10kb) Multiome | 193 | |
| chr10:44,310,666–44,311,727 | 74.0 kb | Distal (>10kb) Multiome | 508 | |
| chr10:44,316,299–44,317,126 | 68.4 kb | Distal (>10kb) Multiome | 149 | |
| chr10:44,370,490–44,371,323 | 14.2 kb | Distal (>10kb) Multiome | 196 | |
| chr10:44,382,126–44,383,352 | 2.6 kb | Proximal (<10kb) Multiome | 183 | |
| chr10:44,383,675–44,387,184 | 57 bp | At TSS Multiome | 522 |
Genomic view of the CXCL12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.