GC1

Gene Cluster 536 genes

Cholesterol and sterol biosynthetic metabolism

This 548-gene module includes HIF1A, ERBB2, CTNNB1, ITGB1, and LDLR, and is enriched for cholesterol biosynthetic process, sterol biosynthetic process, and secondary alcohol biosynthetic process. Knockdown of HIF1A, ERBB2, and CTNNB1 activates this module. No transcription factors show significant repression of this module.

Key terms: secondary alcohol biosynthetic process cholesterol biosynthetic process sterol biosynthetic process COPII-coated vesicle cargo loading intracellular transport Notable genes: HIF1A ERBB2 CTNNB1 ITGB1 LDLR HSPA5 NRAS EPAS1 Top TFs: AFF1 AFF4 AGO1 AGO2 AHDC1

536 member genes 894 TF regulators

TF Regulatory Network

Direction indicates the effect of TF knockdown on this gene cluster (↑ = KD upregulates; ↓ = KD downregulates).

Perturbation + Binding ↑ ↓

Perturbation only ↑ ↓

Binding only

TF	Dir	NES	padj	Bind	OR

Module Genes

Genes assigned to this temporal expression cluster (mfuzz).

Gene	Type	Publications