This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]
Transcription factors with Perturb-seq knockdown data for NRAS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NRAS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NRAS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:114,510,080–114,511,643 | 205.6 kb | Distal (>10kb) Multiome | 977 | |
| chr1:114,581,305–114,582,040 | 135.1 kb | Distal (>10kb) Multiome | 796 | |
| chr1:114,642,026–114,643,180 | 74.3 kb | Distal (>10kb) Multiome | 125 | |
| chr1:114,669,579–114,670,824 | 46.7 kb | Distal (>10kb) Multiome | 605 | |
| chr1:114,716,313–114,717,190 | 56 bp | At TSS Multiome | 869 | |
| chr1:114,756,971–114,758,310 | 41.0 kb | Distal (>10kb) Multiome | 1005 | |
| chr1:114,780,205–114,780,915 | 63.9 kb | Distal (>10kb) Multiome | 869 |
Genomic view of the NRAS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.