This gen encodes a member of the HERC protein family. This protein stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein may be involved in membrane transport processes. [provided by RefSeq, Mar 2012]
Transcription factors with Perturb-seq knockdown data for HERC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HERC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HERC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:63,599,386–63,601,708 | 233.0 kb | Distal (>10kb) Multiome | 832 | |
| chr15:63,833,277–63,834,519 | 35 bp | At TSS Multiome | 873 | |
| chr15:64,045,892–64,046,997 | 212.6 kb | Distal (>10kb) Multiome | 442 | |
| chr15:64,093,386–64,094,387 | 260.0 kb | Distal (>10kb) Multiome | 765 | |
| chr15:64,095,741–64,096,612 | 262.1 kb | Distal (>10kb) Multiome | 839 |
Genomic view of the HERC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.