This gene was identified by its similarity to the ST7 tumor suppressor gene found in the chromosome 7q31 region. This gene is clustered in a tail-to-tail manner with the WNT2B gene in a chromosomal region known to be deleted and rearranged in a variety of cancers. Several transcript variants encoding many different isoforms have been described, but some have not been fully characterized. [provided by RefSeq, Feb 2011]
Transcription factors with Perturb-seq knockdown data for ST7L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ST7L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ST7L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:112,369,701–112,370,152 | 249.8 kb | Distal (>10kb) Multiome | 364 | |
| chr1:112,390,678–112,391,531 | 228.7 kb | Distal (>10kb) Multiome | 470 | |
| chr1:112,395,753–112,396,890 | 223.5 kb | Distal (>10kb) Multiome | 600 | |
| chr1:112,465,931–112,466,532 | 153.4 kb | Distal (>10kb) Multiome | 686 | |
| chr1:112,501,804–112,502,551 | 117.5 kb | Distal (>10kb) Multiome | 420 | |
| chr1:112,507,925–112,508,314 | 111.6 kb | Distal (>10kb) Multiome | 122 | |
| chr1:112,508,429–112,509,558 | 110.7 kb | Distal (>10kb) Multiome | 413 | |
| chr1:112,524,298–112,524,779 | 95.2 kb | Distal (>10kb) Multiome | 127 | |
| chr1:112,618,652–112,620,129 | 86 bp | At TSS Multiome | 956 | |
| chr1:112,674,125–112,675,737 | 55.7 kb | Distal (>10kb) Multiome | 910 | |
| chr1:112,700,203–112,701,476 | 81.2 kb | Distal (>10kb) Multiome | 765 | |
| chr1:112,704,514–112,705,591 | 85.5 kb | Distal (>10kb) Multiome | 694 | |
| chr1:112,706,536–112,707,966 | 87.6 kb | Distal (>10kb) Multiome | 784 | |
| chr1:112,714,149–112,716,774 | 96.9 kb | Distal (>10kb) Multiome | 765 | |
| chr1:112,743,679–112,744,585 | 124.5 kb | Distal (>10kb) Multiome | 198 | |
| chr1:112,790,881–112,791,569 | 171.6 kb | Distal (>10kb) Multiome | 158 | |
| chr1:112,794,180–112,795,498 | 175.4 kb | Distal (>10kb) Multiome | 251 | |
| chr1:112,809,091–112,810,187 | 190.0 kb | Distal (>10kb) Multiome | 445 | |
| chr1:112,817,716–112,818,473 | 198.5 kb | Distal (>10kb) Multiome | 249 | |
| chr1:112,819,120–112,820,730 | 199.8 kb | Distal (>10kb) Multiome | 456 | |
| chr1:112,825,474–112,826,954 | 206.3 kb | Distal (>10kb) Multiome | 182 | |
| chr1:112,841,024–112,841,798 | 221.7 kb | Distal (>10kb) Multiome | 215 | |
| chr1:112,849,324–112,850,157 | 230.1 kb | Distal (>10kb) Multiome | 352 |
Genomic view of the ST7L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.