Enables several functions, including L-amino acid transmembrane transporter activity; cholesterol binding activity; and guanyl-nucleotide exchange factor activity. Involved in carboxylic acid transport; cellular response to amino acid stimulus; and positive regulation of TORC1 signaling. Located in Ragulator complex; late endosome; and lysosomal membrane. Part of FNIP-folliculin RagC/D GAP. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLC38A9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC38A9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC38A9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:55,307,204–55,308,263 | 404.6 kb | Distal (>10kb) Multiome HiCAR | 873 | |
| chr5:55,484,537–55,485,441 | 227.5 kb | Distal (>10kb) Multiome | 208 | |
| chr5:55,497,392–55,498,099 | 214.6 kb | Distal (>10kb) Multiome | 88 | |
| chr5:55,534,173–55,536,366 | 177.3 kb | Distal (>10kb) Multiome | 894 | |
| chr5:55,615,856–55,616,949 | 95.9 kb | Distal (>10kb) Multiome | 117 | |
| chr5:55,625,096–55,625,790 | 86.9 kb | Distal (>10kb) Multiome | 142 | |
| chr5:55,711,869–55,712,819 | 84 bp | At TSS Multiome | 772 | |
| chr5:55,994,462–55,995,686 | 282.7 kb | Distal (>10kb) Multiome | 975 |
Genomic view of the SLC38A9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.