The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PTPRS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTPRS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTPRS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:5,048,124–5,048,589 | 292.4 kb | Distal (>10kb) Multiome HiCAR | 444 | |
| chr19:5,292,734–5,294,422 | 47.5 kb | Distal (>10kb) Multiome | 506 | |
| chr19:5,338,619–5,339,278 | 1.5 kb | Proximal (<10kb) | 150 | |
| chr19:5,339,639–5,341,408 | 40 bp | At TSS Multiome | 966 | |
| chr19:5,397,820–5,398,866 | 57.6 kb | Distal (>10kb) Multiome | 137 | |
| chr19:5,436,304–5,437,277 | 96.0 kb | Distal (>10kb) Multiome | 227 | |
| chr19:5,536,326–5,536,869 | 195.8 kb | Distal (>10kb) Multiome HiCAR | 306 | |
| chr19:5,567,504–5,568,201 | 227.0 kb | Distal (>10kb) Multiome | 209 | |
| chr19:5,585,656–5,586,338 | 245.2 kb | Distal (>10kb) Multiome | 267 | |
| chr19:5,621,964–5,623,739 | 282.1 kb | Distal (>10kb) Multiome | 857 | |
| chr19:6,458,960–6,460,940 | 1119.6 kb | Distal (>10kb) Multiome HiCAR | 859 |
Genomic view of the PTPRS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.