Predicted to enable guanyl-nucleotide exchange factor adaptor activity. Predicted to be involved in positive regulation of Rac protein signal transduction and positive regulation of guanyl-nucleotide exchange factor activity. Predicted to act upstream of or within several processes, including bone resorption; negative regulation of Rho protein signal transduction; and podosome assembly. Located in cytosol and focal adhesion. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for TNS3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TNS3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TNS3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:47,327,527–47,328,581 | 254.5 kb | Distal (>10kb) Multiome | 292 | |
| chr7:47,438,490–47,439,340 | 143.8 kb | Distal (>10kb) Multiome | 75 | |
| chr7:47,470,443–47,471,472 | 111.8 kb | Distal (>10kb) Multiome | 474 | |
| chr7:47,536,825–47,537,767 | 45.2 kb | Distal (>10kb) Multiome | 220 | |
| chr7:47,541,081–47,541,794 | 41.0 kb | Distal (>10kb) Multiome | 131 | |
| chr7:47,573,047–47,573,300 | 9.3 kb | Proximal (<10kb) | 111 | |
| chr7:47,575,995–47,576,471 | 6.1 kb | Proximal (<10kb) | 520 | |
| chr7:47,580,977–47,582,681 | 449 bp | At TSS Multiome | 540 |
Genomic view of the TNS3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.