Cofactor D is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TBCD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TBCD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TBCD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:82,458,067–82,459,318 | 293.5 kb | Distal (>10kb) Multiome | 1054 | |
| chr17:82,494,122–82,495,128 | 257.4 kb | Distal (>10kb) Multiome | 1010 | |
| chr17:82,496,968–82,497,781 | 254.7 kb | Distal (>10kb) Multiome | 613 | |
| chr17:82,519,154–82,520,226 | 232.5 kb | Distal (>10kb) Multiome | 869 | |
| chr17:82,647,682–82,648,684 | 103.4 kb | Distal (>10kb) Multiome | 874 | |
| chr17:82,697,983–82,699,271 | 53.2 kb | Distal (>10kb) Multiome | 623 | |
| chr17:82,715,983–82,717,178 | 35.5 kb | Distal (>10kb) Multiome | 744 | |
| chr17:82,735,174–82,736,034 | 16.5 kb | Distal (>10kb) Multiome | 649 | |
| chr17:82,751,094–82,752,780 | 315 bp | At TSS Multiome | 987 | |
| chr17:82,754,308–82,754,605 | 2.2 kb | Proximal (<10kb) | 35 | |
| chr17:82,754,710–82,755,244 | 2.9 kb | Proximal (<10kb) Multiome | 188 | |
| chr17:83,050,838–83,052,451 | 299.8 kb | Distal (>10kb) Multiome | 912 |
Genomic view of the TBCD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.