Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol; nuclear membrane; and nucleoplasm. Part of MLL1 complex and NSL complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PHF20. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PHF20 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PHF20, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:35,539,672–35,540,321 | 232.0 kb | Distal (>10kb) Multiome | 311 | |
| chr20:35,541,280–35,542,685 | 229.9 kb | Distal (>10kb) Multiome | 849 | |
| chr20:35,600,739–35,601,999 | 170.4 kb | Distal (>10kb) Multiome | 575 | |
| chr20:35,604,921–35,605,589 | 166.7 kb | Distal (>10kb) Multiome | 27 | |
| chr20:35,615,559–35,617,919 | 154.2 kb | Distal (>10kb) Multiome | 1169 | |
| chr20:35,618,589–35,619,849 | 152.5 kb | Distal (>10kb) Multiome | 865 | |
| chr20:35,664,428–35,665,171 | 107.1 kb | Distal (>10kb) Multiome | 1018 | |
| chr20:35,698,724–35,699,893 | 72.6 kb | Distal (>10kb) Multiome | 1035 | |
| chr20:35,741,564–35,742,903 | 29.6 kb | Distal (>10kb) Multiome | 1145 | |
| chr20:35,769,101–35,769,560 | 2.7 kb | Proximal (<10kb) Multiome | 415 | |
| chr20:35,771,622–35,772,463 | 101 bp | At TSS Multiome | 998 | |
| chr20:35,773,423–35,773,596 | 1.4 kb | Proximal (<10kb) | 218 | |
| chr20:35,953,663–35,955,230 | 182.6 kb | Distal (>10kb) Multiome | 1166 | |
| chr20:36,010,700–36,011,324 | 239.0 kb | Distal (>10kb) Multiome | 70 | |
| chr20:36,050,468–36,051,316 | 279.0 kb | Distal (>10kb) Multiome | 1033 | |
| chr20:36,064,282–36,065,619 | 292.8 kb | Distal (>10kb) Multiome | 798 |
Genomic view of the PHF20 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.