Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Predicted to be involved in cardiac muscle cell development. Predicted to be active in nucleus. Implicated in hypertrophic cardiomyopathy 27. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ALPK3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ALPK3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ALPK3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:84,570,159–84,571,300 | 246.4 kb | Distal (>10kb) Multiome | 730 | |
| chr15:84,587,808–84,588,502 | 229.2 kb | Distal (>10kb) Multiome | 357 | |
| chr15:84,600,331–84,601,554 | 216.4 kb | Distal (>10kb) Multiome | 827 | |
| chr15:84,603,386–84,604,192 | 213.6 kb | Distal (>10kb) Multiome | 119 | |
| chr15:84,630,983–84,631,898 | 186.0 kb | Distal (>10kb) Multiome | 649 | |
| chr15:84,633,275–84,634,337 | 183.6 kb | Distal (>10kb) Multiome | 621 | |
| chr15:84,653,715–84,654,595 | 163.0 kb | Distal (>10kb) Multiome HiCAR | 788 | |
| chr15:84,657,788–84,658,916 | 159.0 kb | Distal (>10kb) Multiome HiCAR | 591 | |
| chr15:84,715,472–84,717,226 | 101.0 kb | Distal (>10kb) Multiome | 972 | |
| chr15:84,734,887–84,735,749 | 82.2 kb | Distal (>10kb) Multiome | 614 | |
| chr15:84,747,459–84,749,457 | 68.9 kb | Distal (>10kb) Multiome | 852 | |
| chr15:84,816,861–84,818,557 | 428 bp | At TSS Multiome | 375 | |
| chr15:84,819,344–84,819,583 | 2.0 kb | Proximal (<10kb) | 73 | |
| chr15:84,826,399–84,826,594 | 9.0 kb | Proximal (<10kb) | 242 | |
| chr15:84,928,071–84,928,522 | 111.0 kb | Distal (>10kb) Multiome | 445 | |
| chr15:84,960,290–84,961,237 | 143.4 kb | Distal (>10kb) Multiome | 222 | |
| chr15:84,980,278–84,982,611 | 163.9 kb | Distal (>10kb) Multiome | 1106 |
Genomic view of the ALPK3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.