This 20-gene module includes highly studied genes TYMS, PCNA, FEN1, RRM2, and DEK, with strong enrichment for DNA replication, cell cycle DNA replication, and DNA-templated DNA replication processes. Knockdown of SMAD5, SOX17, GRHL2, HNF1B, and FOXH1 activates this module. Knockdown of SNAI1 represses this module.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.