The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PCNA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PCNA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PCNA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:4,822,174–4,824,353 | 296.3 kb | Distal (>10kb) Multiome | 588 | |
| chr20:4,912,668–4,913,330 | 207.0 kb | Distal (>10kb) Multiome | 53 | |
| chr20:5,000,957–5,002,039 | 118.4 kb | Distal (>10kb) Multiome | 553 | |
| chr20:5,112,796–5,113,601 | 6.8 kb | Proximal (<10kb) Multiome | 1034 | |
| chr20:5,119,153–5,120,492 | 32 bp | At TSS Multiome | 1100 | |
| chr20:5,126,122–5,128,043 | 6.8 kb | Proximal (<10kb) Multiome | 1011 | |
| chr20:5,315,859–5,317,317 | 196.8 kb | Distal (>10kb) Multiome | 273 |
Genomic view of the PCNA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.