This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]
Transcription factors with Perturb-seq knockdown data for RRM2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RRM2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RRM2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:9,843,034–9,844,039 | 279.2 kb | Distal (>10kb) Multiome | 965 | |
| chr2:9,950,478–9,952,371 | 171.2 kb | Distal (>10kb) Multiome | 704 | |
| chr2:10,042,279–10,044,590 | 78.6 kb | Distal (>10kb) Multiome | 999 | |
| chr2:10,057,234–10,058,147 | 65.0 kb | Distal (>10kb) Multiome | 504 | |
| chr2:10,079,477–10,080,916 | 42.7 kb | Distal (>10kb) Multiome | 381 | |
| chr2:10,097,234–10,097,850 | 25.2 kb | Distal (>10kb) Multiome | 372 | |
| chr2:10,120,050–10,120,940 | 2.3 kb | Proximal (<10kb) Multiome | 1054 | |
| chr2:10,121,967–10,123,307 | 92 bp | At TSS Multiome | 958 | |
| chr2:10,301,765–10,304,331 | 180.0 kb | Distal (>10kb) Multiome | 899 | |
| chr2:10,409,111–10,409,643 | 286.6 kb | Distal (>10kb) Multiome | 552 | |
| chr2:10,432,300–10,432,926 | 309.9 kb | Distal (>10kb) Multiome HiCAR | 273 | |
| chr2:10,434,743–10,435,398 | 312.4 kb | Distal (>10kb) Multiome HiCAR | 526 |
Genomic view of the RRM2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.