This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for GMNN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GMNN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GMNN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:24,494,447–24,495,849 | 279.8 kb | Distal (>10kb) Multiome | 946 | |
| chr6:24,630,916–24,631,933 | 143.5 kb | Distal (>10kb) Multiome | 80 | |
| chr6:24,645,624–24,646,552 | 128.8 kb | Distal (>10kb) Multiome | 641 | |
| chr6:24,666,308–24,667,466 | 108.0 kb | Distal (>10kb) Multiome | 1037 | |
| chr6:24,719,378–24,722,053 | 53.7 kb | Distal (>10kb) Multiome | 1238 | |
| chr6:24,774,256–24,775,895 | 237 bp | At TSS Multiome | 1073 | |
| chr6:24,910,313–24,911,578 | 136.1 kb | Distal (>10kb) Multiome | 372 | |
| chr6:24,980,508–24,981,759 | 206.2 kb | Distal (>10kb) Multiome | 163 |
Genomic view of the GMNN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.