Enables chromatin binding activity and molecular adaptor activity. Involved in several processes, including DNA metabolic process; centrosome cycle; and response to UV. Located in centrosome; nucleus; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PCLAF. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PCLAF upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PCLAF, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:64,093,386–64,094,387 | 287.5 kb | Distal (>10kb) Multiome | 765 | |
| chr15:64,095,741–64,096,612 | 285.5 kb | Distal (>10kb) Multiome | 839 | |
| chr15:64,146,930–64,147,642 | 234.2 kb | Distal (>10kb) Multiome | 403 | |
| chr15:64,151,111–64,152,828 | 229.8 kb | Distal (>10kb) Multiome HiCAR | 586 | |
| chr15:64,152,948–64,154,154 | 227.7 kb | Distal (>10kb) Multiome HiCAR | 593 | |
| chr15:64,162,530–64,163,834 | 218.3 kb | Distal (>10kb) Multiome HiCAR | 876 | |
| chr15:64,355,477–64,356,649 | 25.2 kb | Distal (>10kb) Multiome | 748 | |
| chr15:64,381,037–64,381,737 | 60 bp | At TSS Multiome | 630 | |
| chr15:64,387,554–64,388,126 | 6.3 kb | Proximal (<10kb) Multiome | 1137 | |
| chr15:64,430,220–64,430,746 | 49.0 kb | Distal (>10kb) Multiome | 350 | |
| chr15:64,460,117–64,462,256 | 80.5 kb | Distal (>10kb) Multiome | 930 | |
| chr15:64,588,906–64,589,753 | 207.9 kb | Distal (>10kb) Multiome | 112 | |
| chr15:64,634,613–64,635,221 | 253.4 kb | Distal (>10kb) Multiome | 309 |
Genomic view of the PCLAF locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.