Enables calcium ion binding activity; non-membrane spanning protein tyrosine kinase activity; and protein serine/threonine kinase activity. Involved in apoptotic process; cell population proliferation; and protein autophosphorylation. Located in cell cortex and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MELK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MELK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MELK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:36,400,210–36,402,094 | 171.9 kb | Distal (>10kb) Multiome HiCAR | 864 | |
| chr9:36,415,916–36,416,528 | 156.7 kb | Distal (>10kb) Multiome | 55 | |
| chr9:36,486,561–36,488,558 | 85.1 kb | Distal (>10kb) Multiome | 733 | |
| chr9:36,572,530–36,573,276 | 47 bp | At TSS Multiome | 736 | |
| chr9:36,765,822–36,766,468 | 193.2 kb | Distal (>10kb) Multiome | 470 |
Genomic view of the MELK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.