This module contains 22 genes including INSR, AIM2, DGCR8, MYO9B, and VAV2, with top enriched terms related to insulin receptor signaling pathway and innate immune response. Knockdown of SOX17 activates this module, while knockdown of EOMES and FOXA2 repress it. The module's regulatory logic suggests coordinate control of metabolic and immune functions during endoderm differentiation.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.