VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Transcription factors with Perturb-seq knockdown data for VAV2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VAV2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VAV2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:133,738,059–133,738,688 | 254.0 kb | Distal (>10kb) Multiome HiCAR | 451 | |
| chr9:133,991,125–133,993,807 | 394 bp | At TSS Multiome | 819 | |
| chr9:133,994,258–133,994,669 | 1.9 kb | Proximal (<10kb) | 432 | |
| chr9:134,024,630–134,026,342 | 32.9 kb | Distal (>10kb) Multiome | 742 | |
| chr9:134,067,300–134,068,908 | 75.9 kb | Distal (>10kb) Multiome | 721 | |
| chr9:134,135,166–134,136,822 | 143.7 kb | Distal (>10kb) Multiome | 790 |
Genomic view of the VAV2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.