This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Transcription factors with Perturb-seq knockdown data for DGCR8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DGCR8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DGCR8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:19,854,381–19,855,705 | 225.3 kb | Distal (>10kb) Multiome | 1014 | |
| chr22:19,891,576–19,892,031 | 188.5 kb | Distal (>10kb) Multiome | 631 | |
| chr22:19,959,058–19,959,828 | 120.8 kb | Distal (>10kb) Multiome | 576 | |
| chr22:19,962,339–19,962,798 | 117.7 kb | Distal (>10kb) Multiome | 442 | |
| chr22:19,986,350–19,987,426 | 93.1 kb | Distal (>10kb) Multiome | 539 | |
| chr22:20,016,068–20,017,437 | 63.4 kb | Distal (>10kb) Multiome | 640 | |
| chr22:20,020,662–20,021,745 | 59.3 kb | Distal (>10kb) Multiome | 718 | |
| chr22:20,079,663–20,080,743 | 145 bp | At TSS Multiome | 994 | |
| chr22:20,116,628–20,118,048 | 37.1 kb | Distal (>10kb) Multiome | 999 | |
| chr22:20,130,806–20,131,896 | 50.9 kb | Distal (>10kb) Multiome | 525 | |
| chr22:20,203,393–20,204,086 | 123.5 kb | Distal (>10kb) Multiome | 292 | |
| chr22:20,243,636–20,244,300 | 163.7 kb | Distal (>10kb) Multiome | 251 | |
| chr22:20,267,373–20,268,700 | 188.1 kb | Distal (>10kb) Multiome | 449 | |
| chr22:20,298,366–20,300,076 | 218.9 kb | Distal (>10kb) Multiome | 538 | |
| chr22:20,319,527–20,320,815 | 239.8 kb | Distal (>10kb) Multiome | 805 |
Genomic view of the DGCR8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.