Enables transcription coactivator activity and transcription corepressor activity. Involved in cell cycle G1/S phase transition and positive regulation of transcription by RNA polymerase II. Located in Cajal body; Gemini of Cajal bodies; and cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NPAT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NPAT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NPAT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:107,927,906–107,929,475 | 294.3 kb | Distal (>10kb) Multiome | 653 | |
| chr11:108,008,534–108,009,915 | 213.6 kb | Distal (>10kb) Multiome | 1031 | |
| chr11:108,121,137–108,122,070 | 101.1 kb | Distal (>10kb) Multiome | 878 | |
| chr11:108,219,058–108,219,457 | 3.2 kb | Proximal (<10kb) | 78 | |
| chr11:108,221,947–108,224,257 | 222 bp | At TSS Multiome | 939 | |
| chr11:108,467,108–108,468,105 | 244.9 kb | Distal (>10kb) Multiome | 756 | |
| chr11:108,497,307–108,498,913 | 275.2 kb | Distal (>10kb) Multiome | 959 | |
| chr11:108,664,315–108,665,549 | 442.4 kb | Distal (>10kb) Multiome HiCAR | 672 |
Genomic view of the NPAT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.