AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for AIM2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AIM2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AIM2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:158,149,364–158,150,151 | 926.9 kb | Distal (>10kb) Multiome HiCAR | 421 | |
| chr1:158,177,403–158,178,263 | 898.9 kb | Distal (>10kb) Multiome HiCAR | 195 | |
| chr1:158,180,618–158,181,838 | 895.6 kb | Distal (>10kb) Multiome HiCAR | 321 | |
| chr1:158,999,415–159,000,347 | 76.9 kb | Distal (>10kb) Multiome HiCAR | 267 | |
| chr1:159,005,384–159,006,879 | 70.8 kb | Distal (>10kb) Multiome HiCAR | 342 | |
| chr1:159,171,210–159,173,452 | 94.9 kb | Distal (>10kb) Multiome | 251 | |
| chr1:159,187,164–159,189,000 | 111.8 kb | Distal (>10kb) Multiome | 228 | |
| chr1:159,196,646–159,196,825 | 8.8 kb | Proximal (<10kb) | 23 | |
| chr1:159,197,827–159,198,457 | 10.0 kb | Proximal (<10kb) | 190 |
Genomic view of the AIM2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.