This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for MYO9B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYO9B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYO9B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:16,828,911–16,830,011 | 246.4 kb | Distal (>10kb) Multiome | 623 | |
| chr19:16,895,945–16,898,066 | 178.5 kb | Distal (>10kb) Multiome | 632 | |
| chr19:17,074,934–17,076,532 | 173 bp | At TSS Multiome | 890 | |
| chr19:17,209,430–17,210,427 | 134.0 kb | Distal (>10kb) Multiome | 245 | |
| chr19:17,215,005–17,215,979 | 139.7 kb | Distal (>10kb) Multiome | 897 | |
| chr19:17,225,705–17,226,889 | 150.6 kb | Distal (>10kb) Multiome | 870 | |
| chr19:17,234,748–17,236,650 | 160.1 kb | Distal (>10kb) Multiome | 612 | |
| chr19:17,244,882–17,247,104 | 170.4 kb | Distal (>10kb) Multiome | 862 | |
| chr19:17,247,935–17,248,860 | 172.8 kb | Distal (>10kb) Multiome | 588 | |
| chr19:17,266,931–17,267,755 | 191.5 kb | Distal (>10kb) Multiome | 720 | |
| chr19:17,281,537–17,283,120 | 207.0 kb | Distal (>10kb) Multiome | 669 | |
| chr19:17,292,242–17,293,049 | 216.9 kb | Distal (>10kb) Multiome | 513 | |
| chr19:17,302,721–17,303,771 | 227.7 kb | Distal (>10kb) Multiome | 636 | |
| chr19:17,305,286–17,306,514 | 229.9 kb | Distal (>10kb) Multiome | 947 | |
| chr19:17,309,159–17,310,151 | 233.7 kb | Distal (>10kb) Multiome | 741 | |
| chr19:17,327,532–17,329,548 | 252.2 kb | Distal (>10kb) Multiome | 370 | |
| chr19:17,334,287–17,335,052 | 259.0 kb | Distal (>10kb) Multiome | 870 | |
| chr19:17,336,574–17,338,240 | 261.7 kb | Distal (>10kb) Multiome | 924 | |
| chr19:17,340,311–17,341,226 | 264.9 kb | Distal (>10kb) Multiome | 419 |
Genomic view of the MYO9B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.