EML2

EMAP like 2 | ELP70, EMAP-2, EMAP2

Enables microtubule binding activity. Involved in negative regulation of microtubule polymerization and regulation of microtubule nucleation. Located in mitotic spindle. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-5 DE-5.19

Biological processes 15 terms

cytoskeleton (GO:0005856)microtubule associated complex (GO:0005875)microtubule binding (GO:0008017)microtubule binding (GO:0008017)microtubule binding (GO:0008017)microtubule cytoskeleton organization (GO:0000226)mitotic spindle (GO:0072686)mitotic spindle (GO:0072686)negative regulation of microtubule polymerization (GO:0031115)protein binding (GO:0005515)regulation of microtubule nucleation (GO:0010968)sensory perception of sound (GO:0007605)spindle (GO:0005819)tubulin binding (GO:0015631)visual perception (GO:0007601)

Expression (TPM)

TFs regulating EML2 0 TFs

Transcription factors with Perturb-seq knockdown data for EML2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EML2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to EML2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EML2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:45,340,431–45,341,201	304.8 kb	Distal (>10kb) Multiome	363
chr19:45,370,064–45,371,122	274.9 kb	Distal (>10kb) Multiome	592
chr19:45,402,280–45,402,828	243.1 kb	Distal (>10kb) Multiome	332
chr19:45,403,781–45,404,684	241.6 kb	Distal (>10kb) Multiome	494
chr19:45,404,818–45,406,887	239.1 kb	Distal (>10kb) Multiome	964
chr19:45,423,326–45,424,545	221.9 kb	Distal (>10kb) Multiome	996
chr19:45,439,539–45,440,189	205.8 kb	Distal (>10kb) Multiome	718
chr19:45,443,052–45,444,768	202.1 kb	Distal (>10kb) Multiome	857
chr19:45,450,695–45,451,265	194.7 kb	Distal (>10kb) Multiome	515
chr19:45,455,706–45,456,201	189.6 kb	Distal (>10kb) Multiome	776
chr19:45,467,169–45,468,696	177.9 kb	Distal (>10kb) Multiome	686
chr19:45,468,843–45,470,312	176.2 kb	Distal (>10kb) Multiome	769
chr19:45,478,416–45,479,276	166.8 kb	Distal (>10kb) Multiome	809
chr19:45,485,144–45,486,070	160.1 kb	Distal (>10kb) Multiome	659
chr19:45,492,647–45,493,344	152.7 kb	Distal (>10kb) Multiome	522
chr19:45,496,247–45,497,677	148.6 kb	Distal (>10kb) Multiome	742
chr19:45,498,270–45,499,916	146.0 kb	Distal (>10kb) Multiome	464
chr19:45,506,243–45,507,963	138.9 kb	Distal (>10kb) Multiome	969
chr19:45,508,291–45,509,751	137.0 kb	Distal (>10kb) Multiome	670
chr19:45,528,315–45,529,353	116.7 kb	Distal (>10kb) Multiome HiCAR	425
chr19:45,584,026–45,585,251	60.9 kb	Distal (>10kb) Multiome	907
chr19:45,607,096–45,607,695	38.2 kb	Distal (>10kb) Multiome	526
chr19:45,615,654–45,616,944	29.5 kb	Distal (>10kb) Multiome	480
chr19:45,632,406–45,633,148	12.9 kb	Distal (>10kb) Multiome	358
chr19:45,638,965–45,639,696	6.3 kb	Proximal (<10kb) Multiome	477
chr19:45,640,813–45,642,557	3.3 kb	Proximal (<10kb) Multiome	865
chr19:45,643,187–45,644,012	2.0 kb	Proximal (<10kb) Multiome	542
chr19:45,645,389–45,646,343	308 bp	At TSS Multiome	566
chr19:45,667,856–45,668,417	22.4 kb	Distal (>10kb) Multiome	386
chr19:45,668,914–45,669,719	23.8 kb	Distal (>10kb) Multiome	611
chr19:45,670,481–45,671,446	25.4 kb	Distal (>10kb) Multiome	361
chr19:45,676,875–45,678,209	31.9 kb	Distal (>10kb) Multiome	418
chr19:45,681,530–45,682,004	36.1 kb	Distal (>10kb) Multiome	648
chr19:45,691,622–45,693,062	46.8 kb	Distal (>10kb) Multiome	943
chr19:45,716,851–45,718,343	71.9 kb	Distal (>10kb) Multiome	895
chr19:45,730,200–45,731,219	85.4 kb	Distal (>10kb) Multiome	740
chr19:45,767,223–45,771,892	123.8 kb	Distal (>10kb) Multiome	1161
chr19:45,779,258–45,780,150	134.0 kb	Distal (>10kb) Multiome	445
chr19:45,792,338–45,793,273	147.3 kb	Distal (>10kb) Multiome	609
chr19:45,815,484–45,818,073	170.3 kb	Distal (>10kb) Multiome	623
chr19:45,862,559–45,864,765	218.8 kb	Distal (>10kb) Multiome	976
chr19:45,881,480–45,883,645	236.5 kb	Distal (>10kb) Multiome	990
chr19:45,885,092–45,887,294	241.1 kb	Distal (>10kb) Multiome	913
chr19:45,901,212–45,903,471	257.2 kb	Distal (>10kb) Multiome	780
chr19:47,483,636–47,484,543	1838.6 kb	Distal (>10kb) Multiome HiCAR	841

Genome Browser

Genomic view of the EML2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.