This gene encodes one of six engulfment and motility (ELMO) domain-containing proteins. This gene is thought to play a role in antiviral responses. Mutations in this gene may be involved in the cause of familial idiopathic pulmonary fibrosis. [provided by RefSeq, Sep 2010]
Transcription factors with Perturb-seq knockdown data for ELMOD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ELMOD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ELMOD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:140,237,447–140,238,937 | 286.4 kb | Distal (>10kb) Multiome | 397 | |
| chr4:140,252,035–140,253,792 | 271.0 kb | Distal (>10kb) Multiome | 580 | |
| chr4:140,349,706–140,350,239 | 174.2 kb | Distal (>10kb) Multiome | 64 | |
| chr4:140,357,429–140,358,616 | 166.1 kb | Distal (>10kb) Multiome | 90 | |
| chr4:140,372,701–140,374,405 | 150.6 kb | Distal (>10kb) Multiome | 837 | |
| chr4:140,426,688–140,428,067 | 96.5 kb | Distal (>10kb) Multiome | 896 | |
| chr4:140,497,533–140,498,453 | 26.2 kb | Distal (>10kb) Multiome | 183 | |
| chr4:140,515,302–140,516,703 | 7.8 kb | Proximal (<10kb) Multiome | 90 | |
| chr4:140,523,657–140,524,734 | 54 bp | At TSS Multiome | 865 | |
| chr4:140,567,710–140,569,432 | 44.9 kb | Distal (>10kb) Multiome | 331 | |
| chr4:140,594,849–140,595,496 | 71.0 kb | Distal (>10kb) Multiome | 205 | |
| chr4:140,640,083–140,640,873 | 116.3 kb | Distal (>10kb) Multiome | 115 | |
| chr4:140,744,160–140,744,919 | 220.5 kb | Distal (>10kb) Multiome | 148 | |
| chr4:140,755,626–140,757,505 | 231.7 kb | Distal (>10kb) Multiome | 1002 |
Genomic view of the ELMOD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.