Enables ubiquitin protein ligase binding activity. Acts upstream of or within Golgi organization and Golgi to plasma membrane protein transport. Located in Golgi apparatus and nucleoplasm. Biomarker of hepatocellular carcinoma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for BLZF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BLZF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BLZF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:169,105,168–169,107,653 | 261.9 kb | Distal (>10kb) Multiome | 935 | |
| chr1:169,109,651–169,110,604 | 258.1 kb | Distal (>10kb) Multiome | 462 | |
| chr1:169,367,501–169,368,697 | 292 bp | At TSS Multiome | 746 | |
| chr1:169,427,069–169,427,659 | 59.2 kb | Distal (>10kb) Multiome | 258 | |
| chr1:169,485,050–169,486,633 | 117.8 kb | Distal (>10kb) Multiome | 1015 |
Genomic view of the BLZF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.