This gene encodes a lysosomal membrane protein that may be involved in the transport and metabolism of cobalamin. This protein also interacts with the large form of the hepatitis delta antigen and may be required for the nucleocytoplasmic shuttling of the hepatitis delta virus. Mutations in this gene are associated with the vitamin B12 metabolism disorder termed, homocystinuria-megaloblastic anemia complementation type F.[provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for LMBRD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LMBRD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LMBRD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:69,772,473–69,773,363 | 24.0 kb | Distal (>10kb) Multiome | 196 | |
| chr6:69,791,075–69,791,406 | 5.5 kb | Proximal (<10kb) | 39 | |
| chr6:69,795,596–69,797,518 | 44 bp | At TSS Multiome | 832 | |
| chr6:69,801,281–69,801,499 | 4.4 kb | Proximal (<10kb) | 28 | |
| chr6:69,866,356–69,868,081 | 70.6 kb | Distal (>10kb) Multiome | 609 | |
| chr6:69,913,505–69,914,577 | 117.2 kb | Distal (>10kb) Multiome | 173 |
Genomic view of the LMBRD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.