This gene encodes a protein that contains ankyrin repeats and coiled coil domains and likely plays a role in apoptosis. Studies in rodents have implicated the encoded protein in the stimulation of apoptosis and the regulation of mammary gland involution, in which the mammary gland returns to its pre-pregnant state. This protein has also been proposed to negatively regulate apoptosis based on experiments in human cell lines in which the protein was shown to interact with PRKC apoptosis WT1 regulator protein, also known as PAR-4, and inhibit translocation of the PAR-4 receptor. Autoantibodies to this protein have been identified in human patients with panuveitis and Graves' disease. Differential expression of this gene has been observed in various human cancers. [provided by RefSeq, May 2017]
Transcription factors with Perturb-seq knockdown data for UACA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UACA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UACA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:70,451,955–70,452,474 | 311.3 kb | Distal (>10kb) Multiome | 142 | |
| chr15:70,505,637–70,506,328 | 257.4 kb | Distal (>10kb) Multiome | 305 | |
| chr15:70,584,932–70,585,627 | 178.1 kb | Distal (>10kb) Multiome | 463 | |
| chr15:70,703,691–70,704,125 | 4.0 kb | Proximal (<10kb) | 54 | |
| chr15:70,704,228–70,704,487 | 4.6 kb | Proximal (<10kb) | 55 | |
| chr15:70,762,521–70,764,044 | 187 bp | At TSS Multiome | 805 | |
| chr15:70,853,264–70,854,729 | 90.7 kb | Distal (>10kb) Multiome | 472 | |
| chr15:70,891,888–70,893,094 | 129.2 kb | Distal (>10kb) Multiome | 794 |
Genomic view of the UACA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.