Enables identical protein binding activity. Predicted to be involved in cilium assembly and regulation of microtubule cytoskeleton organization. Located in centrosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CEP70. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CEP70 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CEP70, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:138,329,184–138,330,233 | 264.4 kb | Distal (>10kb) Multiome | 580 | |
| chr3:138,347,955–138,349,547 | 245.8 kb | Distal (>10kb) Multiome | 615 | |
| chr3:138,417,585–138,418,044 | 176.5 kb | Distal (>10kb) Multiome | 243 | |
| chr3:138,434,084–138,435,298 | 159.7 kb | Distal (>10kb) Multiome | 811 | |
| chr3:138,608,484–138,609,385 | 14.7 kb | Distal (>10kb) Multiome | 803 | |
| chr3:138,834,175–138,835,445 | 240.6 kb | Distal (>10kb) Multiome | 868 | |
| chr3:138,861,682–138,863,746 | 268.6 kb | Distal (>10kb) Multiome | 879 | |
| chr3:138,879,509–138,880,571 | 285.7 kb | Distal (>10kb) Multiome | 216 | |
| chr3:138,914,877–138,916,650 | 321.6 kb | Distal (>10kb) Multiome HiCAR | 922 | |
| chr3:138,935,795–138,937,399 | 342.0 kb | Distal (>10kb) Multiome HiCAR | 594 | |
| chr3:138,937,821–138,938,914 | 344.1 kb | Distal (>10kb) Multiome HiCAR | 119 | |
| chr3:138,944,879–138,947,892 | 353.0 kb | Distal (>10kb) Multiome HiCAR | 500 | |
| chr3:138,949,729–138,950,605 | 356.0 kb | Distal (>10kb) Multiome HiCAR | 149 |
Genomic view of the CEP70 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.