This module contains 12 genes including ROR1, LAMA1, FNDC3B, MCC, and ADAMTS12, with top enrichment in extracellular matrix organization, cell adhesion, and receptor signaling. Knockdown of SOX17 activates this module, while knockdown of NANOG represses it. The module's focus on matrix and adhesion components suggests roles in cell-cell interactions and tissue organization during endoderm differentiation.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.