Enables RNA binding activity. Predicted to act upstream of or within several processes, including negative regulation of osteoblast differentiation; substrate adhesion-dependent cell spreading; and type II pneumocyte differentiation. Predicted to be located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FNDC3B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FNDC3B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FNDC3B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:171,809,388–171,811,048 | 230.2 kb | Distal (>10kb) Multiome | 995 | |
| chr3:171,829,986–171,830,451 | 210.3 kb | Distal (>10kb) Multiome HiCAR | 553 | |
| chr3:171,935,156–171,936,124 | 104.8 kb | Distal (>10kb) Multiome HiCAR | 174 | |
| chr3:172,038,874–172,041,199 | 1.0 kb | Proximal (<10kb) Multiome | 971 | |
| chr3:172,140,446–172,141,377 | 100.4 kb | Distal (>10kb) Multiome | 850 |
Genomic view of the FNDC3B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.