This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ADAMTS12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ADAMTS12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ADAMTS12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:33,440,328–33,441,918 | 451.1 kb | Distal (>10kb) Multiome HiCAR | 971 | |
| chr5:33,886,524–33,886,789 | 5.2 kb | Proximal (<10kb) | 13 | |
| chr5:33,890,125–33,890,447 | 1.6 kb | Proximal (<10kb) | 61 | |
| chr5:33,890,772–33,890,937 | 1.1 kb | Proximal (<10kb) | 32 | |
| chr5:33,891,468–33,892,881 | 199 bp | At TSS Multiome | 260 | |
| chr5:33,901,435–33,901,794 | 9.4 kb | Proximal (<10kb) | 25 | |
| chr5:33,929,045–33,930,097 | 37.6 kb | Distal (>10kb) Multiome HiCAR | 81 | |
| chr5:33,935,991–33,936,950 | 44.2 kb | Distal (>10kb) Multiome HiCAR | 282 | |
| chr5:34,007,535–34,008,720 | 116.1 kb | Distal (>10kb) Multiome | 987 |
Genomic view of the ADAMTS12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.