Predicted to enable single-stranded DNA binding activity and transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SSBP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SSBP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SSBP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:54,121,133–54,122,207 | 284.8 kb | Distal (>10kb) Multiome | 490 | |
| chr1:54,199,512–54,200,664 | 206.3 kb | Distal (>10kb) Multiome | 741 | |
| chr1:54,405,024–54,410,267 | 3.1 kb | Proximal (<10kb) Multiome | 991 | |
| chr1:54,411,735–54,412,248 | 5.5 kb | Proximal (<10kb) Multiome | 104 | |
| chr1:54,474,500–54,475,180 | 68.5 kb | Distal (>10kb) Multiome | 231 | |
| chr1:54,487,606–54,488,753 | 81.9 kb | Distal (>10kb) Multiome HiCAR | 766 | |
| chr1:54,488,856–54,491,244 | 83.1 kb | Distal (>10kb) Multiome HiCAR | 749 | |
| chr1:54,541,930–54,543,207 | 136.0 kb | Distal (>10kb) Multiome | 769 |
Genomic view of the SSBP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.