This gene encodes a member of the atrophin family of arginine-glutamic acid (RE) dipeptide repeat-containing proteins. The encoded protein co-localizes with a transcription factor in the nucleus, and its overexpression triggers apoptosis. A similar protein in mouse associates with histone deacetylase and is thought to function as a transcriptional co-repressor during embryonic development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RERE. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RERE upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RERE, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:8,166,706–8,167,855 | 650.2 kb | Distal (>10kb) Multiome | 348 | |
| chr1:8,216,976–8,217,707 | 600.4 kb | Distal (>10kb) Multiome | 224 | |
| chr1:8,423,281–8,424,459 | 393.6 kb | Distal (>10kb) Multiome HiCAR | 635 | |
| chr1:8,424,580–8,425,281 | 914 bp | At TSS | 353 | |
| chr1:8,438,982–8,439,949 | 378.3 kb | Distal (>10kb) Multiome HiCAR | 366 | |
| chr1:8,563,315–8,564,272 | 253.6 kb | Distal (>10kb) Multiome HiCAR | 300 | |
| chr1:8,702,848–8,703,691 | 114.2 kb | Distal (>10kb) Multiome HiCAR | 839 | |
| chr1:8,817,213–8,818,248 | 185 bp | At TSS Multiome | 791 | |
| chr1:8,848,753–8,849,552 | 31.5 kb | Distal (>10kb) Multiome | 603 | |
| chr1:8,855,525–8,856,275 | 38.2 kb | Distal (>10kb) Multiome | 37 | |
| chr1:8,873,547–8,874,366 | 56.4 kb | Distal (>10kb) Multiome | 473 | |
| chr1:8,877,947–8,879,611 | 61.4 kb | Distal (>10kb) Multiome | 1144 |
Genomic view of the RERE locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.