This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MCC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MCC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MCC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:113,203,000–113,203,846 | 91.5 kb | Distal (>10kb) Multiome HiCAR | 546 | |
| chr5:113,207,437–113,207,946 | 4.1 kb | Proximal (<10kb) | 13 | |
| chr5:113,210,825–113,211,275 | 7.5 kb | Proximal (<10kb) | 18 | |
| chr5:113,268,808–113,270,132 | 25.5 kb | Distal (>10kb) Multiome | 232 | |
| chr5:113,292,979–113,295,151 | 6 bp | At TSS Multiome | 614 | |
| chr5:113,299,670–113,299,916 | 4.7 kb | Proximal (<10kb) | 8 | |
| chr5:113,478,732–113,478,992 | 9.5 kb | Proximal (<10kb) | 22 | |
| chr5:113,487,322–113,489,078 | 193.5 kb | Distal (>10kb) Multiome | 675 | |
| chr5:113,513,389–113,514,484 | 218.8 kb | Distal (>10kb) Multiome | 862 | |
| chr5:113,606,227–113,606,835 | 311.7 kb | Distal (>10kb) Multiome | 306 |
Genomic view of the MCC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.