This module contains 26 genes including PDGFRA, SEMA4D, SDC2, and SLC12A2, enriched for mesenchymal signaling, cell migration, and developmental processes. Knockdown of ARID1A and SMAD3 activates this module. Knockdown of DR1, HNF1B, ZNF644, SOX4, and SOX11 represses this module.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.