The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Transcription factors with Perturb-seq knockdown data for SLC12A2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC12A2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC12A2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:127,934,861–127,935,426 | 148.7 kb | Distal (>10kb) Multiome HiCAR | 524 | |
| chr5:128,081,661–128,081,788 | 2.0 kb | Proximal (<10kb) | 62 | |
| chr5:128,081,997–128,082,382 | 1.4 kb | Proximal (<10kb) | 94 | |
| chr5:128,082,728–128,084,994 | 110 bp | At TSS Multiome | 915 | |
| chr5:128,200,690–128,202,024 | 117.6 kb | Distal (>10kb) Multiome | 518 |
Genomic view of the SLC12A2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.