Enables identical protein binding activity; semaphorin receptor binding activity; and transmembrane signaling receptor activity. Involved in several processes, including positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; regulation of neuron projection development; and regulation of primary metabolic process. Located in microtubule organizing center; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SEMA4D. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SEMA4D upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SEMA4D, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:89,225,983–89,226,479 | 271.8 kb | Distal (>10kb) Multiome | 72 | |
| chr9:89,295,298–89,295,875 | 202.5 kb | Distal (>10kb) Multiome | 98 | |
| chr9:89,310,238–89,311,866 | 187.2 kb | Distal (>10kb) Multiome | 945 | |
| chr9:89,317,972–89,319,093 | 179.5 kb | Distal (>10kb) Multiome | 1083 | |
| chr9:89,435,291–89,435,862 | 62.6 kb | Distal (>10kb) Multiome HiCAR | 216 | |
| chr9:89,497,231–89,498,509 | 64 bp | At TSS Multiome | 374 | |
| chr9:89,603,012–89,604,575 | 105.0 kb | Distal (>10kb) Multiome | 537 | |
| chr9:89,604,751–89,607,232 | 108.7 kb | Distal (>10kb) Multiome | 689 | |
| chr9:89,661,587–89,662,555 | 164.0 kb | Distal (>10kb) Multiome | 313 | |
| chr9:89,675,046–89,675,613 | 177.1 kb | Distal (>10kb) Multiome | 98 | |
| chr9:89,677,983–89,678,537 | 180.1 kb | Distal (>10kb) Multiome | 119 | |
| chr9:89,705,274–89,706,387 | 207.6 kb | Distal (>10kb) Multiome | 54 |
Genomic view of the SEMA4D locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.