This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]
Transcription factors with Perturb-seq knockdown data for PDGFRA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PDGFRA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PDGFRA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:54,063,729–54,065,237 | 212.5 kb | Distal (>10kb) Multiome | 809 | |
| chr4:54,066,651–54,067,574 | 210.2 kb | Distal (>10kb) Multiome | 296 | |
| chr4:54,103,204–54,104,370 | 173.5 kb | Distal (>10kb) Multiome | 120 | |
| chr4:54,197,150–54,197,872 | 79.6 kb | Distal (>10kb) Multiome | 125 | |
| chr4:54,215,002–54,215,966 | 61.6 kb | Distal (>10kb) Multiome | 130 | |
| chr4:54,217,474–54,218,395 | 59.3 kb | Distal (>10kb) Multiome | 422 | |
| chr4:54,225,346–54,226,488 | 2.8 kb | Proximal (<10kb) | 90 | |
| chr4:54,226,597–54,228,751 | 50.2 kb | Distal (>10kb) Multiome | 426 | |
| chr4:54,228,948–54,229,403 | at TSS | At TSS | 138 | |
| chr4:54,229,771–54,234,753 | 44.0 kb | Distal (>10kb) Multiome | 713 | |
| chr4:54,234,977–54,235,133 | 5.7 kb | Proximal (<10kb) | 16 | |
| chr4:54,566,399–54,567,204 | 289.6 kb | Distal (>10kb) Multiome | 197 |
Genomic view of the PDGFRA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.