The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SDC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SDC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SDC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:96,235,143–96,236,137 | 258.2 kb | Distal (>10kb) Multiome | 677 | |
| chr8:96,261,159–96,263,004 | 232.1 kb | Distal (>10kb) Multiome | 1100 | |
| chr8:96,281,343–96,281,988 | 212.5 kb | Distal (>10kb) Multiome | 137 | |
| chr8:96,327,549–96,328,440 | 165.8 kb | Distal (>10kb) Multiome | 453 | |
| chr8:96,493,060–96,495,549 | 92 bp | At TSS Multiome | 801 | |
| chr8:96,644,505–96,645,984 | 151.5 kb | Distal (>10kb) Multiome | 986 | |
| chr8:97,231,860–97,233,116 | 738.6 kb | Distal (>10kb) Multiome HiCAR | 331 |
Genomic view of the SDC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.