Enables AP-1 adaptor complex binding activity and kinesin binding activity. Involved in negative regulation of receptor recycling and vesicle targeting, trans-Golgi to endosome. Acts upstream of or within negative regulation of substrate adhesion-dependent cell spreading. Located in Golgi apparatus and transport vesicle. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for AP1AR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AP1AR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AP1AR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:112,144,918–112,146,313 | 86.3 kb | Distal (>10kb) Multiome | 652 | |
| chr4:112,230,957–112,232,763 | 26 bp | At TSS Multiome | 1055 | |
| chr4:112,235,127–112,235,293 | 3.3 kb | Proximal (<10kb) | 128 | |
| chr4:112,285,498–112,286,312 | 54.1 kb | Distal (>10kb) Multiome | 695 | |
| chr4:112,361,159–112,361,926 | 129.8 kb | Distal (>10kb) Multiome | 209 | |
| chr4:112,378,884–112,379,732 | 147.5 kb | Distal (>10kb) Multiome | 230 | |
| chr4:112,509,466–112,511,736 | 279.2 kb | Distal (>10kb) Multiome | 299 | |
| chr4:112,514,488–112,516,977 | 284.8 kb | Distal (>10kb) Multiome | 586 | |
| chr4:112,522,782–112,524,704 | 292.3 kb | Distal (>10kb) Multiome | 638 |
Genomic view of the AP1AR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.