This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Transcription factors with Perturb-seq knockdown data for SDHA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SDHA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SDHA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:52,897–54,263 | 164.6 kb | Distal (>10kb) Multiome | 379 | |
| chr5:91,673–92,358 | 126.2 kb | Distal (>10kb) Multiome | 279 | |
| chr5:188,610–189,107 | 29.5 kb | Distal (>10kb) Multiome | 472 | |
| chr5:217,613–219,286 | 114 bp | At TSS Multiome | 692 | |
| chr5:271,018–272,107 | 53.1 kb | Distal (>10kb) Multiome | 866 | |
| chr5:320,742–322,619 | 103.3 kb | Distal (>10kb) Multiome | 441 | |
| chr5:472,056–474,135 | 254.8 kb | Distal (>10kb) Multiome | 964 |
Genomic view of the SDHA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.