Enables ATP binding activity; magnesium ion binding activity; and protein kinase activity. Involved in intracellular signal transduction and protein autophosphorylation. Is active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SIK2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SIK2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SIK2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:111,422,866–111,423,519 | 179.3 kb | Distal (>10kb) Multiome | 486 | |
| chr11:111,454,630–111,455,561 | 147.5 kb | Distal (>10kb) Multiome | 244 | |
| chr11:111,511,983–111,513,416 | 89.7 kb | Distal (>10kb) Multiome | 255 | |
| chr11:111,514,437–111,515,063 | 87.7 kb | Distal (>10kb) Multiome | 141 | |
| chr11:111,540,033–111,542,250 | 61.7 kb | Distal (>10kb) Multiome | 425 | |
| chr11:111,592,552–111,592,865 | 9.6 kb | Proximal (<10kb) | 20 | |
| chr11:111,601,692–111,603,359 | 142 bp | At TSS Multiome | 853 | |
| chr11:111,604,478–111,604,674 | 2.0 kb | Proximal (<10kb) | 186 | |
| chr11:111,765,276–111,766,937 | 164.0 kb | Distal (>10kb) Multiome HiCAR | 726 | |
| chr11:111,784,858–111,785,661 | 182.8 kb | Distal (>10kb) Multiome HiCAR | 164 | |
| chr11:111,870,839–111,871,692 | 268.8 kb | Distal (>10kb) Multiome | 781 | |
| chr11:111,878,459–111,879,798 | 276.7 kb | Distal (>10kb) Multiome | 970 |
Genomic view of the SIK2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.