Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PIP4K2A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIP4K2A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIP4K2A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:22,436,581–22,437,900 | 277.5 kb | Distal (>10kb) Multiome | 649 | |
| chr10:22,475,784–22,478,185 | 236.9 kb | Distal (>10kb) Multiome | 345 | |
| chr10:22,513,530–22,514,377 | 200.6 kb | Distal (>10kb) Multiome | 268 | |
| chr10:22,646,171–22,647,089 | 67.9 kb | Distal (>10kb) Multiome | 138 | |
| chr10:22,690,919–22,691,399 | 23.5 kb | Distal (>10kb) Multiome | 100 | |
| chr10:22,705,948–22,706,483 | 8.1 kb | Proximal (<10kb) | 86 | |
| chr10:22,712,886–22,715,283 | 4 bp | At TSS Multiome | 719 | |
| chr10:22,810,644–22,811,385 | 96.3 kb | Distal (>10kb) Multiome | 202 | |
| chr10:22,897,054–22,897,738 | 182.9 kb | Distal (>10kb) Multiome | 105 | |
| chr10:22,927,465–22,928,426 | 213.4 kb | Distal (>10kb) Multiome | 411 |
Genomic view of the PIP4K2A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.