The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for KPNA4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KPNA4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KPNA4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:160,398,871–160,400,586 | 166.1 kb | Distal (>10kb) Multiome | 790 | |
| chr3:160,448,903–160,450,623 | 115.6 kb | Distal (>10kb) Multiome | 864 | |
| chr3:160,564,297–160,566,417 | 180 bp | At TSS Multiome | 933 | |
| chr3:160,676,210–160,677,318 | 111.3 kb | Distal (>10kb) Multiome | 203 | |
| chr3:160,754,343–160,757,897 | 190.1 kb | Distal (>10kb) Multiome | 899 | |
| chr3:160,796,249–160,797,170 | 231.3 kb | Distal (>10kb) Multiome | 413 |
Genomic view of the KPNA4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.