Enables histone reader activity and methylated histone binding activity. Involved in positive regulation of DNA-templated transcription; positive regulation of Wnt signaling pathway; and rRNA transcription. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for SPIN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SPIN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SPIN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:88,378,157–88,378,715 | 9.9 kb | Proximal (<10kb) Multiome | 185 | |
| chr9:88,387,373–88,389,406 | 113 bp | At TSS Multiome | 788 | |
| chr9:88,513,907–88,514,605 | 125.7 kb | Distal (>10kb) Multiome | 158 | |
| chr9:88,533,926–88,536,159 | 146.6 kb | Distal (>10kb) Multiome HiCAR | 510 | |
| chr9:88,551,452–88,552,214 | 163.4 kb | Distal (>10kb) Multiome | 137 |
Genomic view of the SPIN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.